Tuning Monoclonal Antibody Galactosylation utilizing Raman Spectroscopy-Managed Lactic Acid Feeding
A key side of large-scale manufacturing of biotherapeutics is a well-designed and consistently-executed upstream cell tradition course of. Course of Analytical Know-how (PAT) instruments present enhanced monitoring and management capabilities to assist constant course of execution, and still have potential to assist in upkeep of product high quality at desired ranges.
One such software, Raman spectroscopy, has matured as a helpful approach to attain real-time monitoring and management of key cell tradition course of attributes. We developed a Raman spectroscopy-based nutrient management technique to allow twin management of lactate and glucose ranges for a fed-batch CHO cell tradition course of for monoclonal antibody (mAb) manufacturing.
To realize this, PLS-based chemometric fashions for real-time prediction of glucose and lactate concentrations had been developed and deployed in suggestions management loops. Specifically, feeding of lactic acid post-metabolic shift was investigated primarily based on earlier work that has proven the impression of lactate ranges on ammonium in addition to mAb product high quality.
Three feeding methods had been assessed for impression on cell metabolism, productiveness, and product high quality: bolus-fed glucose, glucose management at four g/L, or simultaneous glucose management at four g/L and lactate management at 2 g/L. The third feeding technique resulted in a big discount in ammonium ranges (68%) whereas rising mAb galactosylation ranges by roughly 50%.
This work demonstrated that when deployed in a cell tradition course of, Raman spectroscopy is an efficient approach for simultaneous management of a number of nutrient feeds, and that lactic acid feeding can have a optimistic impression on each cell metabolism and mAb product high quality. This text is protected by copyright. All rights reserved.
PON1 mouse monoclonal antibody, clone OTI1F7 (formerly 1F7) |
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| TA502611 | Origene Technologies GmbH | 100 µl | Ask for price |
PON1 mouse monoclonal antibody, clone OTI1F7 (formerly 1F7) |
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| TA502611S | Origene Technologies GmbH | 30 µl | Ask for price |
PON1 mouse monoclonal antibody, clone OTI2A9 (formerly 2A9) |
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| TA502612 | Origene Technologies GmbH | 100 µl | Ask for price |
PON1 mouse monoclonal antibody, clone OTI2A9 (formerly 2A9) |
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| TA502612S | Origene Technologies GmbH | 30 µl | Ask for price |
Monoclonal PON1 Antibody, Clone: 4G8D3 |
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| AMR09437G | Leading Biology | 0.1ml | EUR 633.6 |
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Description: A Monoclonal antibody against Human PON1. The antibodies are raised in Mouse and are from clone 4G8D3. This antibody is applicable in WB and IHC, FC, ICC, E |
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Rabbit Anti Human PON1 Monoclonal Clone ACAG-16 |
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| IRBAHUPON1ACAG16C100UL | Innovative research | each | EUR 496 |
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Description: Rabbit Anti Human PON1 Monoclonal Clone ACAG-16 |
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Monoclonal PON1 Antibody, Clone: 4G8A12 |
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| AMM02955G | Leading Biology | 0.1ml | EUR 633.6 |
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Description: A Monoclonal antibody against Human PON1. The antibodies are raised in Mouse and are from clone 4G8A12. This antibody is applicable in WB and IHC, FC, E |
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Monoclonal Antibody to Paraoxonase 1 (PON1) |
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| MAA243Ra21 | Cloud-Clone | 100ul | EUR 253 |
PON1 Mouse Monoclonal Antibody |
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| E10-30571 | EnoGene | 100 μl | EUR 275 |
|
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
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PON1 Capture mouse monoclonal antibody, ELISA and Luminex validated, clone OTI1F7 |
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| TA600112 | Origene Technologies GmbH | 100 µg | Ask for price |
PON1 Capture mouse monoclonal antibody, ELISA and Luminex validated, clone OTI2A6 |
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| TA600113 | Origene Technologies GmbH | 100 µg | Ask for price |
PON1 Capture mouse monoclonal antibody, ELISA and Luminex validated, clone OTI2D4 |
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| TA600114 | Origene Technologies GmbH | 100 µg | Ask for price |
Anti-PON1 Mouse Monoclonal Antibody [Clone ID: OTI1F7] |
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| M00516-4 | BosterBio | 100ul | EUR 523 |
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Description: Boster Bio PON1 mouse monoclonal antibody, clone OTI1F7 (formerly 1F7). Catalog# M00516-4. Tested in ELISA, FC, IHC, WB. This antibody reacts with Human. |
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Anti-PON1 Mouse Monoclonal Antibody [Clone ID: OTI2D4] |
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| M00516-5 | BosterBio | 100ul | EUR 523 |
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Description: Boster Bio PON1 mouse monoclonal antibody, clone OTI2D4 (formerly 2D4). Catalog# M00516-5. Tested in ELISA, FC, IF, IHC, WB. This antibody reacts with Human. |
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Mouse Monoclonal Antibody to PON1 |
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| E10-30571A | EnoGene | 100ul | EUR 225 |
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Description: Available in various conjugation types. |
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Mouse Monoclonal Antibody to PON1 |
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| E10-30572 | EnoGene | 100ul | EUR 225 |
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Description: Available in various conjugation types. |
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Mouse Monoclonal Antibody to PON1 |
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| sAP-0865 | Angio Proteomie | 50ug | EUR 270 |
Mouse Monoclonal Antibody to PON1 |
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| sAP-0866 | Angio Proteomie | 50ug | EUR 270 |
Mouse Monoclonal Antibody to PON1 |
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| MBS8527855-01mL | MyBiosource | 0.1mL | EUR 305 |
Mouse Monoclonal Antibody to PON1 |
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| MBS8527855-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 565 |
Mouse Monoclonal Antibody to PON1 |
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| MBS8527855-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 565 |
Mouse Monoclonal Antibody to PON1 |
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| MBS8527855-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 565 |
Mouse Monoclonal Antibody to PON1 |
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| MBS8527855-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 565 |
Mouse Monoclonal Antibody to PON1 |
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| MBS8527856-01mL | MyBiosource | 0.1mL | EUR 305 |
Mouse Monoclonal Antibody to PON1 |
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| MBS8527856-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 565 |
Mouse Monoclonal Antibody to PON1 |
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| MBS8527856-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 565 |
Mouse Monoclonal Antibody to PON1 |
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| MBS8527856-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 565 |
Mouse Monoclonal Antibody to PON1 |
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| MBS8527856-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 565 |
Mouse Monoclonal PON1 Antibody (4G8D3) |
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| TA336952 | Origene Technologies GmbH | 100 µl | Ask for price |
Carrier-free (BSA/glycerol-free) PON1 mouse monoclonal antibody, clone OTI2D4 (formerly 2D4) |
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| CF502528 | Origene Technologies GmbH | 100 µg | Ask for price |
Carrier-free (BSA/glycerol-free) PON1 mouse monoclonal antibody, clone OTI2A6 (formerly 2A6) |
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| CF502610 | Origene Technologies GmbH | 100 µg | Ask for price |
Carrier-free (BSA/glycerol-free) PON1 mouse monoclonal antibody, clone OTI1F7 (formerly 1F7) |
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| CF502611 | Origene Technologies GmbH | 100 µg | Ask for price |
Carrier-free (BSA/glycerol-free) PON1 mouse monoclonal antibody, clone OTI2A9 (formerly 2A9) |
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| CF502612 | Origene Technologies GmbH | 100 µg | Ask for price |
PON3 mouse monoclonal antibody,clone OTI1A5 |
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| TA807382 | Origene Technologies GmbH | 100 µl | Ask for price |
PON3 mouse monoclonal antibody,clone OTI1A5 |
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| TA807382S | Origene Technologies GmbH | 30 µl | Ask for price |
PON3 mouse monoclonal antibody,clone OTI1B12 |
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| TA807383 | Origene Technologies GmbH | 100 µl | Ask for price |
PON3 mouse monoclonal antibody,clone OTI1B12 |
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| TA807383S | Origene Technologies GmbH | 30 µl | Ask for price |
Mouse Anti-HCMV gH Monoclonal Antibody, clone MAb 5 |
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| CABT-NS1153 | Creative Diagnostics | 200 μg | EUR 830 |
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Description: Mouse |
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PON1 biotinylated detection antibody, ELISA and Luminex validated mouse monoclonal antibody, clone OTI2A6 |
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| TA700112 | Origene Technologies GmbH | 50 µg | Ask for price |
PON1 biotinylated detection antibody, ELISA and Luminex validated mouse monoclonal antibody, clone OTI2D4 |
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| TA700114 | Origene Technologies GmbH | 50 µg | Ask for price |
Mouse Anti-Ara h1 IgE Monoclonal Antibody (mAb), Clone 2G11G7 |
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| 7153 | Chondrex | 1 mg/ml x 0.1 ml | EUR 246 |
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Description: Allergy |
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Mouse Anti-Ara h1 IgM Monoclonal Antibody (mAb), Clone 3A1E11 |
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| 7154 | Chondrex | 1 mg/ml x 0.1 ml | EUR 246 |
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Description: Allergy |
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Mouse Monoclonal Anti-Mouse CD160 mAb, PE, (clone CNX46-3), (mouse IgG2bk) |
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| MCD160-PE | Alpha Diagnostics | 50 tests | EUR 416.4 |
CD20 (MS4A1) mouse monoclonal antibody, clone mAb 75 |
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| DDX0110P-100 | Origene Technologies GmbH | 100 µg | Ask for price |
KIR2DL4 mouse monoclonal antibody, clone mAb#33, PE |
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| AM26033RP-N | Origene Technologies GmbH | 100 Tests | Ask for price |
Mouse Monoclonal Anti-Mouse CD160 mAb, FITC, (clone CNX46-3), (mouse IgG2bk) |
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| MCD160-F | Alpha Diagnostics | 50 Tests | EUR 489.6 |
KIR2DL4 mouse monoclonal antibody, clone mAb#33, APC |
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| AM26033AC-N | Origene Technologies GmbH | 100 Tests | Ask for price |
Mouse Monoclonal Anti-Mouse CD160 mAb, Biotin, (clone CNX46-3), (mouse IgG2bk) |
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| MCD160-B | Alpha Diagnostics | 100 tests | EUR 562.8 |
PON3 mouse monoclonal antibody, clone OTI4H9 (formerly 4H9) |
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| TA807380 | Origene Technologies GmbH | 100 µl | Ask for price |
PON3 mouse monoclonal antibody, clone OTI4H9 (formerly 4H9) |
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| TA807380S | Origene Technologies GmbH | 30 µl | Ask for price |
PON3 mouse monoclonal antibody, clone OTI5C3 (formerly 5C3) |
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| TA807381 | Origene Technologies GmbH | 100 µl | Ask for price |
PON3 mouse monoclonal antibody, clone OTI5C3 (formerly 5C3) |
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| TA807381S | Origene Technologies GmbH | 30 µl | Ask for price |
PON3 mouse monoclonal antibody, clone OTI5B5 (formerly 5B5) |
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| TA807428 | Origene Technologies GmbH | 100 µl | Ask for price |
PON3 mouse monoclonal antibody, clone OTI5B5 (formerly 5B5) |
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| TA807428S | Origene Technologies GmbH | 30 µl | Ask for price |
Mouse Monoclonal Anti-Mouse CD160 mAb, Purified, (clone CNX46-3), (mouse IgG2bk) |
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| MCD160-M | Alpha Diagnostics | 100 ug | EUR 578.4 |
PON3 mouse monoclonal antibody, clone OTI1F12 (formerly 1F12) |
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| TA807353 | Origene Technologies GmbH | 100 µl | Ask for price |
PON3 mouse monoclonal antibody, clone OTI1F12 (formerly 1F12) |
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| TA807353S | Origene Technologies GmbH | 30 µl | Ask for price |
Mouse Anti Mouse BDNF Monoclonal Clone |
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| IMSAMLBDNFC120UL | Innovative research | each | EUR 341 |
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Description: Mouse Anti Mouse BDNF Monoclonal Clone |
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Mouse Anti Mouse BDNF Monoclonal Clone |
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| MBS8421710-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Mouse Anti-Mouse Myeloperoxidase (MPO) IgM Monoclonal Antibody (mAb), Clone 8B3A6 |
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| 7160 | Chondrex | 1 mg/ml x 0.1 ml | EUR 246 |
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Description: Inflammation |
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Mouse Anti-Mouse Myeloperoxidase (MPO) IgG3 Monoclonal Antibody (mAb), Clone 3B6A10 |
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| 7159 | Chondrex | 1 mg/ml x 0.1 ml | EUR 246 |
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Description: Inflammation |
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KIR2DL4 mouse monoclonal antibody, clone mAb#33, Aff - Purified |
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| AM26033PU-N | Origene Technologies GmbH | 100 µg | Ask for price |
Ferritin mouse monoclonal antibody, clone mAb 44, Aff - Purified |
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| AM26062PU-N | Origene Technologies GmbH | 200 µg | Ask for price |
Mouse Anti Mouse TH Monoclonal Clone 5B7D10 |
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| IMSAMLTH5B7D10C120UL | Innovative research | each | EUR 282 |
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Description: Mouse Anti Mouse TH Monoclonal Clone 5B7D10 |
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Mouse Anti Mouse TH Monoclonal Clone 5B7D10 |
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| MBS8421747-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Mouse Anti Mouse GFAP Monoclonal Clone 3H1 |
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| IMSAMLGFAP3H1C120UL | Innovative research | each | EUR 260 |
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Description: Mouse Anti Mouse GFAP Monoclonal Clone 3H1 |
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Mouse Anti Mouse GFAP Monoclonal Clone 3H1 |
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| MBS8421725-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Rabbit Anti-Human PON1 Monoclonal Antibody |
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| CABT-36017RH | Creative Diagnostics | 100ug | EUR 1008 |
Mouse Anti Mouse tPA Monoclonal Clone H27B6 |
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| IMSAMSTPAH27B6C1MG | Innovative research | each | EUR 595 |
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Description: Mouse Anti Mouse tPA Monoclonal Clone H27B6 |
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Monoclonal Functional BAFF-R (mouse) Antibody, mAb , Clone: 9B9 |
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| APR16043G | Leading Biology | 0.1mg | EUR 633.6 |
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Description: A Monoclonal antibody against Human Functional BAFF-R (mouse), mAb . The antibodies are raised in Purified From Concentrated Hybridoma Tissue Culture Supernatant. and are from clone 9B9. This antibody is applicable in FC |
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Mouse monoclonal Anti-MOZ Clone 127A |
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| TA353278L | Origene Technologies GmbH | 500 µg | Ask for price |
ELISA andLuminex validated biotinylated detection antibody PON1 ELISA and Luminex validated mouse monoclonal antibody, clone OTI1F7 |
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| TA700113 | Origene Technologies GmbH | 50 µg | Ask for price |
Mouse Anti Mouse AIF1 Monoclonal Clone 5G4E7 |
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| IMSAMLAIF15G4E7C120UL | Innovative research | each | EUR 282 |
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Description: Mouse Anti Mouse AIF1 Monoclonal Clone 5G4E7 |
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Mouse Anti Mouse AIF1 Monoclonal Clone 5G4E7 |
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| MBS8421709-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Mouse monoclonal Anti-BCL10 Clone 151 |
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| TA352997L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CDX1 Clone 123a |
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| TA353093L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse Anti-D. pteronyssinus Der p2 IgM Monoclonal Antibody (mAb), Clone 2D2B12 |
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| 7157 | Chondrex | 1 mg/ml x 0.1 ml | EUR 246 |
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Description: Allergy |
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Mouse Anti-D. pteronyssinus Der p1 IgG3 Monoclonal Antibody (mAb), Clone 3H4E1 |
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| 7158 | Chondrex | 1 mg/ml x 0.1 ml | EUR 246 |
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Description: Allergy |
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Mouse Anti Mouse GFAP Monoclonal Clone 2B12F1 |
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| IMSAMLGFAP2B12F1C120UL | Innovative research | each | EUR 282 |
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Description: Mouse Anti Mouse GFAP Monoclonal Clone 2B12F1 |
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Mouse Anti Mouse PPARG Monoclonal Clone 6D7B9 |
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| IMSAMLPPARG6D7B9C120UL | Innovative research | each | EUR 248 |
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Description: Mouse Anti Mouse PPARG Monoclonal Clone 6D7B9 |
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Mouse Anti Mouse GFAP Monoclonal Clone 2B12F1 |
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| MBS8421724-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Mouse Anti Mouse PPARG Monoclonal Clone 6D7B9 |
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| MBS8421743-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Mouse Anti-D. pteronyssinus Der p2 IgG2a Monoclonal Antibody (mAb), Clone 3H8D12 |
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| 7155 | Chondrex | 1 mg/ml x 0.1 ml | EUR 246 |
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Description: Allergy |
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Mouse Anti-D. pteronyssinus Der p2 IgG2b Monoclonal Antibody (mAb), Clone 4C10H3 |
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| 7156 | Chondrex | 1 mg/ml x 0.1 ml | EUR 246 |
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Description: Allergy |
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Mouse monoclonal Anti-Mos Clone S3.1 |
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| TA353341L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse Anti Human TUBB3 Monoclonal Clone |
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| IMSAMLTUBB3C120UL | Innovative research | each | EUR 341 |
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Description: Mouse Anti Human TUBB3 Monoclonal Clone |
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Mouse Anti Human TUBB3 Monoclonal Clone |
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| MBS8421752-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Mouse monoclonal Anti-EMA Clone E29 |
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| TA352816L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CR1 Clone To5 |
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| TA353107L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-p63 Clone BU5 |
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| TA353532L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-XPA Clone 5A2 |
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| TA353547L | Origene Technologies GmbH | 500 µg | Ask for price |
Lipoprotein lipase (LPL) mouse monoclonal antibody, clone Mab-7, Purified |
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| BM5512 | Origene Technologies GmbH | 50 µg | Ask for price |
Mouse monoclonal Anti-FCGR1 Clone 10.1 |
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| TA352787L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-p13 Clone AA10.2 |
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| TA352924L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-ANO5 Clone 5F7 |
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| TA352973L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD68 Clone KP1 |
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| TA353054L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-Cdk1 Clone 3E1.1 |
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| TA353088L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-Cdk2 Clone AN4.3 |
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| TA353089L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD29 Clone 8E3 |
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| TA353270L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-MMP1 Clone 3B6 |
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| TA353335L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-MMP2 Clone 4D3 |
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| TA353336L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-MMP3 Clone 1B4 |
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| TA353337L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-MMP9 Clone 2C3 |
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| TA353338L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-MUC1 Clone SM3 |
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| TA353346L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-Plx Clone AZ34 |
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| TA353386L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-Plx Clone AZ44 |
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| TA353387L | Origene Technologies GmbH | 500 µg | Ask for price |
PON1 Rabbit Monoclonal Antibody |
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| E10G21865 | EnoGene | 100 μl | EUR 275 |
|
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
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Mouse monoclonal Anti-APC11 Clone AX2.1 |
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| TA352969L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-APC4 Clone CIV1.1 |
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| TA352971L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD19 Clone BU12 |
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| TA353028L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD1c Clone M241 |
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| TA353030L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD22 Clone To15 |
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| TA353036L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD44 Clone P2A1 |
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| TA353042L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD44 Clone BU52 |
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| TA353043L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD70 Clone BU69 |
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| TA353057L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD72 Clone BU40 |
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| TA353059L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD86 Clone BU63 |
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| TA353067L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-Leu2 Clone X107 |
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| TA353072L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-Leu2 Clone BU88 |
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| TA353073L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-Cdk2 Clone AN21.2 |
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| TA353090L | Origene Technologies GmbH | 500 µg | Ask for price |
Structural and practical characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 operate by way of a novel non-competitive mechanism of motion
- Arginase 2 (ARG2) is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of L-arginine. The dysregulated expression of ARG2 inside particular tumor microenvironments generates an immunosuppressive area of interest that successfully renders the tumor ‘invisible’ to the host’s immune system.
- Elevated ARG2 expression results in a concomitant depletion of native L-arginine ranges, which in flip results in suppression of anti-tumor T-cell-mediated immune responses.
- Right here we describe the isolation and characterization of a excessive affinity antibody (C0021158) that inhibits ARG2 enzymatic operate utterly, successfully restoring T-cell proliferation in vitro.
- Enzyme kinetic research confirmed that C0021158 reveals a noncompetitive mechanism of motion, inhibiting ARG2 independently of L-arginine concentrations.
- To elucidate C0021158’s inhibitory mechanism at a structural degree, the co-crystal construction of the Fab in advanced with trimeric ARG2 was solved.
- C0021158’s epitope was consequently mapped to an space a ways from the enzyme’s substrate binding cleft, indicating an allosteric mechanism was being employed. Following C0021158 binding, distinct areas of ARG2 bear main conformational adjustments.
- Notably, the spine construction of a surface-exposed loop is totally rearranged, resulting in the formation of a brand new brief helix construction on the Fab-ARG2 interface.
- Furthermore, this large-scale structural reworking at ARG2’s epitope interprets into extra refined adjustments throughout the enzyme’s energetic website. An arginine residue at place 39 is reoriented inwards, sterically impeding the binding of L-arginine. Arg39 can be predicted to change the pOkA of a key catalytic histidine residue at place 160, additional attenuating ARG2’s enzymatic operate.
- In silicomolecular docking simulations predict that L-arginine is unable to bind successfully when antibody is sure, a prediction supported by isothermal calorimetry experiments utilizing an L-arginine mimetic. Particularly, concentrating on ARG2 within the tumor microenvironment by way of the applying of C0021158, probably together with normal chemotherapy regimens or alternate immunotherapies, represents a possible new technique to focus on immune chilly tumors.
Improvement of a physiologically-based pharmacokinetic mannequin for ocular disposition of monoclonal antibodies in rabbits
- Improvement of protein therapeutics for ocular problems, notably age-related macular degeneration (AMD), is a extremely aggressive and increasing therapeutic space. Nevertheless, the applying of a predictive and translatable ocular PK mannequin to better perceive ocular disposition of protein therapeutics, comparable to a physiologically-based pharmacokinetic (PBPK) mannequin, is lacking from the literature. Right here, we current an growth of an antibody platform PBPK mannequin in the direction of rabbit and incorporate a novel anatomical and physiologically related ocular part.
- Parameters describing all tissues, flows, and binding occasions had been obtained from present literature and glued a priori. First, translation of the platform PBPK mannequin to rabbit was confirmed by evaluating the mannequin’s potential to foretell plasma PK of a systemically administered exogenous antibody.
- Then, the PBPK mannequin with the brand new ocular part was validated by estimation of serum and ocular (i.e. aqueous humor, retina, and vitreous humor) PK of two intravitreally administered monoclonal antibodies. We present that the proposed PBPK mannequin is able to precisely (i.e. inside twofold) predicting ocular publicity of antibody-based medicine. The proposed PBPK mannequin can be utilized for preclinical-to-clinical translation of antibodies developed for ocular problems, and evaluation of ocular toxicity for systemically administered antibody-based therapeutics.
PON1 mouse monoclonal antibody, clone OTI2A9 (formerly 2A9) |
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| TA502612 | Origene Technologies GmbH | 100 µl | Ask for price |
PON1 mouse monoclonal antibody, clone OTI2A9 (formerly 2A9) |
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| TA502612S | Origene Technologies GmbH | 30 µl | Ask for price |
Monoclonal PON1 Antibody, Clone: 4G8D3 |
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| AMR09437G | Leading Biology | 0.1ml | EUR 633.6 |
|
Description: A Monoclonal antibody against Human PON1. The antibodies are raised in Mouse and are from clone 4G8D3. This antibody is applicable in WB and IHC, FC, ICC, E |
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Rabbit Anti Human PON1 Monoclonal Clone ACAG-16 |
|||
| IRBAHUPON1ACAG16C100UL | Innovative research | each | EUR 496 |
|
Description: Rabbit Anti Human PON1 Monoclonal Clone ACAG-16 |
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Monoclonal PON1 Antibody, Clone: 4G8A12 |
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| AMM02955G | Leading Biology | 0.1ml | EUR 633.6 |
|
Description: A Monoclonal antibody against Human PON1. The antibodies are raised in Mouse and are from clone 4G8A12. This antibody is applicable in WB and IHC, FC, E |
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Monoclonal Antibody to Paraoxonase 1 (PON1) |
|||
| MAA243Ra21 | Cloud-Clone | 100ul | EUR 253 |
PON1 Mouse Monoclonal Antibody |
|||
| E10-30571 | EnoGene | 100 μl | EUR 275 |
|
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
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PON1 Capture mouse monoclonal antibody, ELISA and Luminex validated, clone OTI1F7 |
|||
| TA600112 | Origene Technologies GmbH | 100 µg | Ask for price |
PON1 Capture mouse monoclonal antibody, ELISA and Luminex validated, clone OTI2A6 |
|||
| TA600113 | Origene Technologies GmbH | 100 µg | Ask for price |
PON1 Capture mouse monoclonal antibody, ELISA and Luminex validated, clone OTI2D4 |
|||
| TA600114 | Origene Technologies GmbH | 100 µg | Ask for price |
Anti-PON1 Mouse Monoclonal Antibody [Clone ID: OTI1F7] |
|||
| M00516-4 | BosterBio | 100ul | EUR 523 |
|
Description: Boster Bio PON1 mouse monoclonal antibody, clone OTI1F7 (formerly 1F7). Catalog# M00516-4. Tested in ELISA, FC, IHC, WB. This antibody reacts with Human. |
|||
Anti-PON1 Mouse Monoclonal Antibody [Clone ID: OTI2D4] |
|||
| M00516-5 | BosterBio | 100ul | EUR 523 |
|
Description: Boster Bio PON1 mouse monoclonal antibody, clone OTI2D4 (formerly 2D4). Catalog# M00516-5. Tested in ELISA, FC, IF, IHC, WB. This antibody reacts with Human. |
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Mouse Monoclonal Antibody to PON1 |
|||
| E10-30571A | EnoGene | 100ul | EUR 225 |
|
Description: Available in various conjugation types. |
|||
Mouse Monoclonal Antibody to PON1 |
|||
| E10-30572 | EnoGene | 100ul | EUR 225 |
|
Description: Available in various conjugation types. |
|||
Mouse Monoclonal Antibody to PON1 |
|||
| sAP-0865 | Angio Proteomie | 50ug | EUR 270 |
Mouse Monoclonal Antibody to PON1 |
|||
| sAP-0866 | Angio Proteomie | 50ug | EUR 270 |
Mouse Monoclonal Antibody to PON1 |
|||
| MBS8527855-01mL | MyBiosource | 0.1mL | EUR 305 |
Mouse Monoclonal Antibody to PON1 |
|||
| MBS8527855-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 565 |
Mouse Monoclonal Antibody to PON1 |
|||
| MBS8527855-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 565 |
Mouse Monoclonal Antibody to PON1 |
|||
| MBS8527855-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 565 |
Mouse Monoclonal Antibody to PON1 |
|||
| MBS8527855-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 565 |
Mouse Monoclonal Antibody to PON1 |
|||
| MBS8527856-01mL | MyBiosource | 0.1mL | EUR 305 |
Mouse Monoclonal Antibody to PON1 |
|||
| MBS8527856-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 565 |
Mouse Monoclonal Antibody to PON1 |
|||
| MBS8527856-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 565 |
Mouse Monoclonal Antibody to PON1 |
|||
| MBS8527856-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 565 |
Mouse Monoclonal Antibody to PON1 |
|||
| MBS8527856-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 565 |
Mouse Monoclonal PON1 Antibody (4G8D3) |
|||
| TA336952 | Origene Technologies GmbH | 100 µl | Ask for price |
Carrier-free (BSA/glycerol-free) PON1 mouse monoclonal antibody, clone OTI2D4 (formerly 2D4) |
|||
| CF502528 | Origene Technologies GmbH | 100 µg | Ask for price |
Carrier-free (BSA/glycerol-free) PON1 mouse monoclonal antibody, clone OTI2A6 (formerly 2A6) |
|||
| CF502610 | Origene Technologies GmbH | 100 µg | Ask for price |
Carrier-free (BSA/glycerol-free) PON1 mouse monoclonal antibody, clone OTI1F7 (formerly 1F7) |
|||
| CF502611 | Origene Technologies GmbH | 100 µg | Ask for price |
Carrier-free (BSA/glycerol-free) PON1 mouse monoclonal antibody, clone OTI2A9 (formerly 2A9) |
|||
| CF502612 | Origene Technologies GmbH | 100 µg | Ask for price |
PON3 mouse monoclonal antibody,clone OTI1A5 |
|||
| TA807382 | Origene Technologies GmbH | 100 µl | Ask for price |
PON3 mouse monoclonal antibody,clone OTI1A5 |
|||
| TA807382S | Origene Technologies GmbH | 30 µl | Ask for price |
PON3 mouse monoclonal antibody,clone OTI1B12 |
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| TA807383 | Origene Technologies GmbH | 100 µl | Ask for price |
PON3 mouse monoclonal antibody,clone OTI1B12 |
|||
| TA807383S | Origene Technologies GmbH | 30 µl | Ask for price |
Mouse Anti-HCMV gH Monoclonal Antibody, clone MAb 5 |
|||
| CABT-NS1153 | Creative Diagnostics | 200 μg | EUR 830 |
|
Description: Mouse |
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PON1 biotinylated detection antibody, ELISA and Luminex validated mouse monoclonal antibody, clone OTI2A6 |
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| TA700112 | Origene Technologies GmbH | 50 µg | Ask for price |
PON1 biotinylated detection antibody, ELISA and Luminex validated mouse monoclonal antibody, clone OTI2D4 |
|||
| TA700114 | Origene Technologies GmbH | 50 µg | Ask for price |
Mouse Anti-Ara h1 IgE Monoclonal Antibody (mAb), Clone 2G11G7 |
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| 7153 | Chondrex | 1 mg/ml x 0.1 ml | EUR 246 |
|
Description: Allergy |
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Mouse Anti-Ara h1 IgM Monoclonal Antibody (mAb), Clone 3A1E11 |
|||
| 7154 | Chondrex | 1 mg/ml x 0.1 ml | EUR 246 |
|
Description: Allergy |
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Mouse Monoclonal Anti-Mouse CD160 mAb, PE, (clone CNX46-3), (mouse IgG2bk) |
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| MCD160-PE | Alpha Diagnostics | 50 tests | EUR 416.4 |
CD20 (MS4A1) mouse monoclonal antibody, clone mAb 75 |
|||
| DDX0110P-100 | Origene Technologies GmbH | 100 µg | Ask for price |
KIR2DL4 mouse monoclonal antibody, clone mAb#33, PE |
|||
| AM26033RP-N | Origene Technologies GmbH | 100 Tests | Ask for price |
Mouse Monoclonal Anti-Mouse CD160 mAb, FITC, (clone CNX46-3), (mouse IgG2bk) |
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| MCD160-F | Alpha Diagnostics | 50 Tests | EUR 489.6 |
KIR2DL4 mouse monoclonal antibody, clone mAb#33, APC |
|||
| AM26033AC-N | Origene Technologies GmbH | 100 Tests | Ask for price |
Mouse Monoclonal Anti-Mouse CD160 mAb, Biotin, (clone CNX46-3), (mouse IgG2bk) |
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| MCD160-B | Alpha Diagnostics | 100 tests | EUR 562.8 |
PON3 mouse monoclonal antibody, clone OTI4H9 (formerly 4H9) |
|||
| TA807380 | Origene Technologies GmbH | 100 µl | Ask for price |
PON3 mouse monoclonal antibody, clone OTI4H9 (formerly 4H9) |
|||
| TA807380S | Origene Technologies GmbH | 30 µl | Ask for price |
PON3 mouse monoclonal antibody, clone OTI5C3 (formerly 5C3) |
|||
| TA807381 | Origene Technologies GmbH | 100 µl | Ask for price |
PON3 mouse monoclonal antibody, clone OTI5C3 (formerly 5C3) |
|||
| TA807381S | Origene Technologies GmbH | 30 µl | Ask for price |
PON3 mouse monoclonal antibody, clone OTI5B5 (formerly 5B5) |
|||
| TA807428 | Origene Technologies GmbH | 100 µl | Ask for price |
PON3 mouse monoclonal antibody, clone OTI5B5 (formerly 5B5) |
|||
| TA807428S | Origene Technologies GmbH | 30 µl | Ask for price |
Mouse Monoclonal Anti-Mouse CD160 mAb, Purified, (clone CNX46-3), (mouse IgG2bk) |
|||
| MCD160-M | Alpha Diagnostics | 100 ug | EUR 578.4 |
PON3 mouse monoclonal antibody, clone OTI1F12 (formerly 1F12) |
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| TA807353 | Origene Technologies GmbH | 100 µl | Ask for price |
PON3 mouse monoclonal antibody, clone OTI1F12 (formerly 1F12) |
|||
| TA807353S | Origene Technologies GmbH | 30 µl | Ask for price |
Mouse Anti Mouse BDNF Monoclonal Clone |
|||
| IMSAMLBDNFC120UL | Innovative research | each | EUR 341 |
|
Description: Mouse Anti Mouse BDNF Monoclonal Clone |
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Mouse Anti Mouse BDNF Monoclonal Clone |
|||
| MBS8421710-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Mouse Anti-Mouse Myeloperoxidase (MPO) IgM Monoclonal Antibody (mAb), Clone 8B3A6 |
|||
| 7160 | Chondrex | 1 mg/ml x 0.1 ml | EUR 246 |
|
Description: Inflammation |
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Mouse Anti-Mouse Myeloperoxidase (MPO) IgG3 Monoclonal Antibody (mAb), Clone 3B6A10 |
|||
| 7159 | Chondrex | 1 mg/ml x 0.1 ml | EUR 246 |
|
Description: Inflammation |
|||
KIR2DL4 mouse monoclonal antibody, clone mAb#33, Aff - Purified |
|||
| AM26033PU-N | Origene Technologies GmbH | 100 µg | Ask for price |
Ferritin mouse monoclonal antibody, clone mAb 44, Aff - Purified |
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| AM26062PU-N | Origene Technologies GmbH | 200 µg | Ask for price |
Mouse Anti Mouse TH Monoclonal Clone 5B7D10 |
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| IMSAMLTH5B7D10C120UL | Innovative research | each | EUR 282 |
|
Description: Mouse Anti Mouse TH Monoclonal Clone 5B7D10 |
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Mouse Anti Mouse TH Monoclonal Clone 5B7D10 |
|||
| MBS8421747-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Mouse Anti Mouse GFAP Monoclonal Clone 3H1 |
|||
| IMSAMLGFAP3H1C120UL | Innovative research | each | EUR 260 |
|
Description: Mouse Anti Mouse GFAP Monoclonal Clone 3H1 |
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Mouse Anti Mouse GFAP Monoclonal Clone 3H1 |
|||
| MBS8421725-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Rabbit Anti-Human PON1 Monoclonal Antibody |
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| CABT-36017RH | Creative Diagnostics | 100ug | EUR 1008 |
Mouse Anti Mouse tPA Monoclonal Clone H27B6 |
|||
| IMSAMSTPAH27B6C1MG | Innovative research | each | EUR 595 |
|
Description: Mouse Anti Mouse tPA Monoclonal Clone H27B6 |
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Monoclonal Functional BAFF-R (mouse) Antibody, mAb , Clone: 9B9 |
|||
| APR16043G | Leading Biology | 0.1mg | EUR 633.6 |
|
Description: A Monoclonal antibody against Human Functional BAFF-R (mouse), mAb . The antibodies are raised in Purified From Concentrated Hybridoma Tissue Culture Supernatant. and are from clone 9B9. This antibody is applicable in FC |
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Mouse monoclonal Anti-MOZ Clone 127A |
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| TA353278L | Origene Technologies GmbH | 500 µg | Ask for price |
ELISA andLuminex validated biotinylated detection antibody PON1 ELISA and Luminex validated mouse monoclonal antibody, clone OTI1F7 |
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| TA700113 | Origene Technologies GmbH | 50 µg | Ask for price |
Mouse Anti Mouse AIF1 Monoclonal Clone 5G4E7 |
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| IMSAMLAIF15G4E7C120UL | Innovative research | each | EUR 282 |
|
Description: Mouse Anti Mouse AIF1 Monoclonal Clone 5G4E7 |
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Mouse Anti Mouse AIF1 Monoclonal Clone 5G4E7 |
|||
| MBS8421709-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Mouse monoclonal Anti-BCL10 Clone 151 |
|||
| TA352997L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CDX1 Clone 123a |
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| TA353093L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse Anti-D. pteronyssinus Der p2 IgM Monoclonal Antibody (mAb), Clone 2D2B12 |
|||
| 7157 | Chondrex | 1 mg/ml x 0.1 ml | EUR 246 |
|
Description: Allergy |
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Mouse Anti-D. pteronyssinus Der p1 IgG3 Monoclonal Antibody (mAb), Clone 3H4E1 |
|||
| 7158 | Chondrex | 1 mg/ml x 0.1 ml | EUR 246 |
|
Description: Allergy |
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Mouse Anti Mouse GFAP Monoclonal Clone 2B12F1 |
|||
| IMSAMLGFAP2B12F1C120UL | Innovative research | each | EUR 282 |
|
Description: Mouse Anti Mouse GFAP Monoclonal Clone 2B12F1 |
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Mouse Anti Mouse PPARG Monoclonal Clone 6D7B9 |
|||
| IMSAMLPPARG6D7B9C120UL | Innovative research | each | EUR 248 |
|
Description: Mouse Anti Mouse PPARG Monoclonal Clone 6D7B9 |
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Mouse Anti Mouse GFAP Monoclonal Clone 2B12F1 |
|||
| MBS8421724-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Mouse Anti Mouse PPARG Monoclonal Clone 6D7B9 |
|||
| MBS8421743-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Mouse Anti-D. pteronyssinus Der p2 IgG2a Monoclonal Antibody (mAb), Clone 3H8D12 |
|||
| 7155 | Chondrex | 1 mg/ml x 0.1 ml | EUR 246 |
|
Description: Allergy |
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Mouse Anti-D. pteronyssinus Der p2 IgG2b Monoclonal Antibody (mAb), Clone 4C10H3 |
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| 7156 | Chondrex | 1 mg/ml x 0.1 ml | EUR 246 |
|
Description: Allergy |
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Mouse monoclonal Anti-Mos Clone S3.1 |
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| TA353341L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse Anti Human TUBB3 Monoclonal Clone |
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| IMSAMLTUBB3C120UL | Innovative research | each | EUR 341 |
|
Description: Mouse Anti Human TUBB3 Monoclonal Clone |
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Mouse Anti Human TUBB3 Monoclonal Clone |
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| MBS8421752-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Mouse monoclonal Anti-EMA Clone E29 |
|||
| TA352816L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CR1 Clone To5 |
|||
| TA353107L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-p63 Clone BU5 |
|||
| TA353532L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-XPA Clone 5A2 |
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| TA353547L | Origene Technologies GmbH | 500 µg | Ask for price |
Lipoprotein lipase (LPL) mouse monoclonal antibody, clone Mab-7, Purified |
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| BM5512 | Origene Technologies GmbH | 50 µg | Ask for price |
Mouse monoclonal Anti-FCGR1 Clone 10.1 |
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| TA352787L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-p13 Clone AA10.2 |
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| TA352924L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-ANO5 Clone 5F7 |
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| TA352973L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD68 Clone KP1 |
|||
| TA353054L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-Cdk1 Clone 3E1.1 |
|||
| TA353088L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-Cdk2 Clone AN4.3 |
|||
| TA353089L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD29 Clone 8E3 |
|||
| TA353270L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-MMP1 Clone 3B6 |
|||
| TA353335L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-MMP2 Clone 4D3 |
|||
| TA353336L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-MMP3 Clone 1B4 |
|||
| TA353337L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-MMP9 Clone 2C3 |
|||
| TA353338L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-MUC1 Clone SM3 |
|||
| TA353346L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-Plx Clone AZ34 |
|||
| TA353386L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-Plx Clone AZ44 |
|||
| TA353387L | Origene Technologies GmbH | 500 µg | Ask for price |
PON1 Rabbit Monoclonal Antibody |
|||
| E10G21865 | EnoGene | 100 μl | EUR 275 |
|
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
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Mouse monoclonal Anti-APC11 Clone AX2.1 |
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| TA352969L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-APC4 Clone CIV1.1 |
|||
| TA352971L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD19 Clone BU12 |
|||
| TA353028L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD1c Clone M241 |
|||
| TA353030L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD22 Clone To15 |
|||
| TA353036L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD44 Clone P2A1 |
|||
| TA353042L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD44 Clone BU52 |
|||
| TA353043L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD70 Clone BU69 |
|||
| TA353057L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD72 Clone BU40 |
|||
| TA353059L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD86 Clone BU63 |
|||
| TA353067L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-Leu2 Clone X107 |
|||
| TA353072L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-Leu2 Clone BU88 |
|||
| TA353073L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-Cdk2 Clone AN21.2 |
|||
| TA353090L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-BORIS Clone 4A7 |
|||
| TA353114L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CYP2C6 Clone K1 |
|||
| TA353125L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CYP3A1 Clone P6 |
|||
| TA353132L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-NSE Clone NSEP1 |
|||
| TA353161L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-NSE Clone NSEP2 |
|||
| TA353162L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-FGF3 Clone MSD1 |
|||
| TA353194L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-LewisX Clone 28 |
|||
| TA353199L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-INFa Clone ST29 |
|||
| TA353240L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-PCNA Clone PC10 |
|||
| TA353373L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-Cdc20 Clone BA8 |
|||
| TA353388L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-PSMA5 Clone AH1.1 |
|||
| TA353401L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-PTPRC Clone C11 |
|||
| TA353403L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-LAT1 Clone BU53 |
|||
| TA353464L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-TIMP1 Clone 2A5 |
|||
| TA353510L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-TIMP2 Clone 3A4 |
|||
| TA353511L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-WIPI2 Clone 2A2 |
|||
| TA353546L | Origene Technologies GmbH | 500 µg | Ask for price |
*Mouse Anti Mouse Prekallikrein Monoclonal Clone 5G7 |
|||
| IMSAMSPK5G7C100UG | Innovative research | each | EUR 315 |
|
Description: *Mouse Anti Mouse Prekallikrein Monoclonal Clone 5G7 |
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*Mouse Anti Mouse Prekallikrein Monoclonal Clone 5G7 |
|||
| IMSAMSPK5G7C1MG | Innovative research | each | EUR 2516 |
|
Description: *Mouse Anti Mouse Prekallikrein Monoclonal Clone 5G7 |
|||
*Mouse Anti Mouse Prekallikrein Monoclonal Clone 7G2 |
|||
| IMSAMSPK7G2C100UG | Innovative research | each | EUR 315 |
|
Description: *Mouse Anti Mouse Prekallikrein Monoclonal Clone 7G2 |
|||
*Mouse Anti Mouse PAI-1 Monoclonal Clone H14H7 |
|||
| IMSAMSPAI1H14H7C10MG | Innovative research | each | EUR 5964 |
|
Description: *Mouse Anti Mouse PAI-1 Monoclonal Clone H14H7 |
|||
*Mouse Anti Mouse PAI-1 Monoclonal Clone H14H7 |
|||
| IMSAMSPAI1H14H7C1MG | Innovative research | each | EUR 889 |
|
Description: *Mouse Anti Mouse PAI-1 Monoclonal Clone H14H7 |
|||
Mouse Anti Mouse PAI-1 Monoclonal Clone H34G6 |
|||
| IMSAMSPAI1H34G6C10MG | Innovative research | each | EUR 5964 |
|
Description: Mouse Anti Mouse PAI-1 Monoclonal Clone H34G6 |
|||
Mouse Anti Mouse PAI-1 Monoclonal Clone H34G6 |
|||
| IMSAMSPAI1H34G6C1MG | Innovative research | each | EUR 889 |
|
Description: Mouse Anti Mouse PAI-1 Monoclonal Clone H34G6 |
|||
Mouse monoclonal Anti-Leu1 Clone Y2/178 |
|||
| TA353051L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-MHCII Clone BU20 |
|||
| TA352833L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-Mglu3 Clone 4B92.1 |
|||
| TA352845L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-BCRABL Clone 7c6 |
|||
| TA352923L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-ASAP1 Clone 7B12 |
|||
| TA352983L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD22 Clone 4KB71 |
|||
| TA353035L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD44v3 Clone 3D2 |
|||
| TA353046L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD79a Clone HM57 |
|||
| TA353063L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD17a Clone HM47 |
|||
| TA353065L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-PCTAIRE Clone G6.1 |
|||
| TA353087L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CLEC2 Clone AYP1 |
|||
| TA353099 | Origene Technologies GmbH | 100 µg | Ask for price |
Mouse monoclonal Anti-CLEC2 Clone AYP1 |
|||
| TA353099L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CLEC2 Clone AYP2 |
|||
| TA353100L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-Casein Clone F20.14 |
|||
| TA353112L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CYP1A2 Clone D15 |
|||
| TA353117L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-EGFR Clone EGFR1 |
|||
| TA353153L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-HRX Clone HRX107 |
|||
| TA353158L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-ENTPD1 Clone AC2 |
|||
| TA353163L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-EpCAM Clone AUA1 |
|||
| TA353166L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-ErbB3 Clone RTJ2 |
|||
| TA353168L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-ErbB4 Clone HFR1 |
|||
| TA353170L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-hFANCM Clone CV5.1 |
|||
| TA353183L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-FCGR2 Clone KB61 |
|||
| TA353190L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-ICAM3 Clone By44 |
|||
| TA353231L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD49b Clone 16B4 |
|||
| TA353247L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD49b Clone 31H4 |
|||
| TA353248L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD29 Clone 12G10 |
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| TA353269L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-MDM2 Clone SMP14 |
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| TA353329L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD20 Clone PDR78 |
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| TA353342L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-MUC1 Clone HMFG1 |
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| TA353348L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-RIP140 Clone 6D7 |
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| TA353369 | Origene Technologies GmbH | 100 µg | Ask for price |
Mouse monoclonal Anti-RIP140 Clone 6D7 |
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| TA353369L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-PITPNB Clone 4a7 |
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| TA353380L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-PITPNB Clone 1C1 |
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| TA353381L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-PTPRC Clone 2B11 |
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| TA353406L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-PTPRC Clone BU64 |
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| TA353410L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-RACO1 Clone 5H10 |
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| TA353434L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CDw75 Clone ZB55 |
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| TA353475L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-TAL1 Clone BTL73 |
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| TA353479L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-TAL1 Clone 2TL75 |
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| TA353480L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-TIGAR Clone 9C10 |
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| TA353508L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-VEGF Clone VG76e |
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| TA353539L | Origene Technologies GmbH | 500 µg | Ask for price |
*Mouse Anti Mouse Prekallikrein Monoclonal Clone 11H4 |
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| IMSAMSPK11H4C100UG | Innovative research | each | EUR 315 |
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Description: *Mouse Anti Mouse Prekallikrein Monoclonal Clone 11H4 |
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*Mouse Anti Mouse Prekallikrein Monoclonal Clone 11H4 |
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| IMSAMSPK11H4C1MG | Innovative research | each | EUR 2516 |
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Description: *Mouse Anti Mouse Prekallikrein Monoclonal Clone 11H4 |
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*Mouse Anti Mouse Prekallikrein Monoclonal Clone 13G5 |
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| IMSAMSPK13G5C100UG | Innovative research | each | EUR 315 |
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Description: *Mouse Anti Mouse Prekallikrein Monoclonal Clone 13G5 |
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*Mouse Anti Mouse Prekallikrein Monoclonal Clone 13G5 |
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| IMSAMSPK13G5C1MG | Innovative research | each | EUR 2516 |
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Description: *Mouse Anti Mouse Prekallikrein Monoclonal Clone 13G5 |
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*Mouse Anti Mouse Prekallikrein Monoclonal Clone 14E3 |
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| IMSAMSPK14E3CBL100UG | Innovative research | each | EUR 379 |
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Description: *Mouse Anti Mouse Prekallikrein Monoclonal Clone 14E3 |
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*Mouse Anti Mouse Prekallikrein Monoclonal Clone 14E3 |
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| IMSAMSPK14E3CBL1MG | Innovative research | each | EUR 2893 |
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Description: *Mouse Anti Mouse Prekallikrein Monoclonal Clone 14E3 |
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*Mouse Anti Mouse Prekallikrein Monoclonal Clone 3A10 |
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| IMSAMSPK3A10C100UG | Innovative research | each | EUR 315 |
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Description: *Mouse Anti Mouse Prekallikrein Monoclonal Clone 3A10 |
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